In mice with heart failure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy. Increasing ketone ... Increasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary ...

Understanding the Context

Science Daily: Ketone bodies: More than energy, they are powerful signaling metabolites that clean up damaged proteins Ketone bodies are not just about energy. These metabolites are powerful signaling molecules that have profound effects on the proteome and protein quality control in the brain. Scientists, working in ... Ketone bodies: More than energy, they are powerful signaling metabolites that clean up damaged proteins Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities.

Key Insights

Ubiquitous as ... EurekAlert!: People with diabetes or fatty liver disease are less effective at obtaining energy from ketone bodies The liver plays a central role in storing and supplying energy to the body. In type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, commonly referred to as fatty liver ...