Medscape: When Is it Appropriate to Use Methotrexate for Ectopic Pregnancy in the Emergency Department? Methotrexate is a chemotherapeutic agent used as medical therapy for the treatment of ectopic pregnancy. Although it is most commonly administered intramuscularly, obstetricians may inject the ...

Understanding the Context

When Is it Appropriate to Use Methotrexate for Ectopic Pregnancy in the Emergency Department? Overall success rates for intramuscular (IM) methotrexate were comparable between recurrent and primary ectopic pregnancy cases, but single-dose treatment was less effective in recurrent cases. The study suggests a potential benefit of routine multidose methotrexate treatment for recurrent cases of ectopic pregnancy. In summary, methotrexate is appropriate for use as medical therapy for the treatment of ectopic pregnancy in select patients in the ED and is administered as a single-dose intramuscular injection.

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Key Insights

When Is it Appropriate to Use Methotrexate for Ectopic Pregnancy in the ... Is it safe to conceive while the man or woman is taking methotrexate? Dr. Stephen Paget answers this question and reviews which rheumatologic medications are contraindicated in pregnancy. In the 1980s, methotrexate was first used to treat ectopic pregnancies.

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Final Thoughts

A study by Stovall et al., published in 1989, described outpatient treatment of ectopic pregnancy with methotrexate. In this ... From my knowledge and search of the literature, there are no reports on the adverse effects on pregnancy outcomes among men exposed to methotrexate before conception ... Immunomodulators Methotrexate Methotrexate, a pregnancy category X drug, is clearly teratogenic and should not be used in women considering conception. Methotrexate is a folic acid antagonist and ... (San Francisco) — Women with an ectopic pregnancy who take a single dose of methotrexate have outcomes equivalent to those taking the conventional multiple-dose regimen, according ...