Normally where people get burned is that their boards get put in a "condensing" environment even though everything is specified as "non-condensing". But that's not a design problem so much as a specifications issue. tl;dr Don't sweat it and just do your design.

Understanding the Context

Good luck. Hand sweat consists mostly of water and trace amounts of urea, minerals and lactic acid. I would say that lactic acid is a moderate acid with a pka of approx. 3.5, but we are talking trace amounts in sweat.

Key Insights

So, the clock offset won't meaningfully affect your receiver. So, I wouldn't sweat it; if you can get a 26.041 MHz oscillator, that's going to be more than good enough. However, there's also an easy way out here that only needs a much easier to get multiple: generate 40.0 kHz, 60.0 kHz, and a (77.5 - 40.0) kHz = 37.5 kHz Then, depending on the actual skin resistance, due to air humidity, sweat etc, a certain voltage may result in a current that is or is not lethal. You may change the values in the above to your own estimates and compute the current value through the heart as a simple exercise in basic network theory, or run spice. The only people who sweat ground loops are audio types who should be using balanced connections or hierarchical grounds and near DC instrumentation types who again should be separating ground and reference...

Final Thoughts

Note that this applies within a device, external interfaces have other issues. I wonder what the test conditions are (probably "squeaky clean") and what the insulation voltage of a USB-C connector will be in real conditions with a bit of crud, pocket lint, sweat or moisture... Yahoo: I've Worn At Least 50 Runnings Hats In My Life, But These Are My Ride Or Dies "Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." I’ve always appreciated a good hat. Bad hair day? Grab a cap. Freezing outside?

A beanie is the answer.